包虫病相关影响因素Meta分析
Meta-analysis on Potential Risk Factors Associated with Human Echinococcosis
  
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中文摘要:
      为综合定量评价我国西部人群包虫病影响因素,从而为预防和控制人群包虫病提供循证依据,以“包虫病”与“危险因素”或“风险因素”或“影响因素”,“echinococcosis” and “risk factor” and “China”为检索策略,收集国内外已发表的关于包虫病影响因素的研究文献,应用随机或固定效应模型,综合定量评价各影响因素的作用。最终纳入19篇文献,包含121 799名研究对象,其中包虫病病例3 777人,涉及13个影响因素。分析结果显示:对于囊型包虫病,相关性较大的影响因素合并后OR值及95%CI依次是“密切接触犬”2.66(1.71~4.15),“用病畜内脏喂犬”2.48(1.84~3.33),“饭前不洗手”2.12(1.67~2.71),“职业为牧民”2.11(1.43~3.12),其次是“在家中屠宰”“饮用水来自河水或溪水”“家中养犬”等,而“具有高中及以上文化程度” 是保护因素,OR值为0.40(95%CI:0.24~0.65);对于泡型包虫病,关联性较大的影响因素合并后OR值及95%CI依次是“饭前不洗手”2.34(1.76~3.11),“自家养犬”1.96(1.53~2.53),“职业为牧民”1.93(1.28~2.90),“饮用水来自河水或溪水”1.89(1.47~2.44),其次是“密切接触犬”“家周围有野犬”等,而“具有高中及以上文化程度”为保护因素,OR值为0.24(95%CI:0.14~0.42)。分析结果表明,影响西部地区居民包虫病的最主要因素为犬相关因素,如“密切接触犬”“自家养犬”“病畜内脏喂犬”,其次是饮食相关因素,如“饭前不洗手”“饮用河水或溪水”等。本研究对于选择包虫病主要风险因素进行宣传、控制和干预提供了参考。
英文摘要:
      In order to investigate the risk factors associated with human echinococcosis in western China and to provide evidences for further preventing and controlling echinococcosis,a meta-analysis was carried out. By retrieving several search terms consisting of“echinococcosis”“risk factor”“influence factor”and“China”,the related articles published in and out of China were collected. Then the random-effect model(REM)and the fixed-effect model(FEM)were selected to evaluate the pooled ORs. Finally,a total of 19 articles involving 121 799 research objects were included in our meta-analysis. Among them,there were 3 777 echinococcosis cases,involving in 13 influence factors. Results showed that,for cystic echinococcosis,the top 4 risk factors and corresponding combined OR and 95%CI were as follows:intimate contact with dogs(2.66,1.71 to 4.15),feeding dogs with viscera of diseased livestock(2.48,1.84 to 3.33),not washing hands before eating(2.12,1.67 to 2.71),occupying in herding(2.11,1.43 to 3.12);followed by some other factors,such as slaughtering livestock at home,drinking river water,keeping dogs at home and so on. On the contrary,having high school education level or above was a protective factor,its combined OR was 0.40(95%CI:0.24 to 0.65). For alveolar echinococcosis,the top 4 risk factors and corresponding combined OR and 95%CI included not washing hands before eating(2.34,1.76 to 3.11),keeping dogs at home(1.96,1.53 to 2.53),occupying in herding(1.93,1.28 to 2.90),drinking river water(1.89,1.47 to 2.44);followed by intimate contact with dogs and stray dogs appeared in surroundings;correspondingly,having high school education level or above was a protective factor,the OR value was 0.24(95%CI:0.14~0.42). In conclusion,the major risk factor for human echinococcosis in western China was related to dogs,such as intimate contact with dog,keeping dogs at home,feeding dogs with viscera;water-related factors could also induce human echinococcosis,such as not washing hands before eating and drinking river water. The study would provide references for choosing main risk factors,so that human echinococcosis would be prevented and controlled.
作者单位
刘平,孙向东,康京丽,王幼明,黄保续  
中文关键词:  包虫病  影响因素  Meta分析
英文关键词:echinococcosis  risk factor  meta-analysis
基金项目:国家重点研发计划项目(2016YFC1201304)
DOI:10.3969/j.issn.1005-944X.2018.10.004
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