In order to evaluate the security and immune effects of the genetically engineering subunit vaccine of hydatid disease，479 8-week-old lambs from 4 pastures in the Bashang area of Chengde City were selected and divided into 2 groups：immunization group（308 lambs）and control group（171 lambs）. Then immunological experiments were carried out. For the lambs in the immunization group，serum samples were selected before the first and booster immunization and at the time of 2，6 and 9 months after the first immunization. For the control group，serum samples were collected before the experiment and at the time of 9 months after the experiment. All these serum samples were used for antibody detection by ELISA kits. Results showed that，after vaccination，individual lambs had a slight immune response. For the lambs in the immunization group，the positive rates of the antibody before the first immunization and booster immunization were 2.27% and 87.16%，respectively；besides，at 2，6 and 9 months after the first immunization，the rates were 99.32%，93.49%，and 86.46%，respectively. For the control group，the antibody positive rates before and after the experiment were 2.34% and 7.93%，respectively. Results showed that，the genetically engineering subunit vaccine of hydatid disease could rapidly induce the lambs to produce antibodies，and the antibodies could last for a long time. After 9 months of immunization，the lambs still maintained high antibody levels. Therefore，the echinococcosis vaccine was safe and had good effects，and could be promoted and applied in the endemic area of echinococcosis.