On June 27，2019，a case of African swine fever（ASF）was reported in a pig slaughterhouse in Shapotou District of Zhongwei City，Ningxia Hui Autonomous Region. Immediately，emergency response teams were respectively organized by relevent departments at all levels（autonomous region，city and district）to response to the epidemic. The affected zones 3 km around the slaughterhouses and relevant farms were defined and blocked，where temporary inspection and disinfection stations were established and personnel was assigned to patrol and watch over；the slaughterhouses and piglet markets were closed，movement of live pigs and issuing of certificates for inspection and quarantine at the place of origin were stopped. Meanwhile，the disposal measures of“pulling out the disease and eliminating its sources”were carried out，including culling the infected，likely suspected and susceptible animals in the affected spot，the premises and materials that might be polluted by pathogens were disinfected or disposed innocuously，and biosafety management and investigation and monitoring were strengthened in swine farms/households in the affected zones. Live pigs were transported to landfills for killing by electric shock and bio-safety disposal was done. The outbreak was further investigated and screened mainly in affected and threatened zones，as well as their adjacent areas and regions where live pigs were traded. The outbreak was effectively controlled with no any spreading under mutual cooperation among all departments. In addition，it was indicated that，based on the experiences from the outbreak，rigorous testing and diagnosis，strict emergency investigation，serious disposal of any outbreak should be guaranteed. In conclusion，some guidance of ASF disposal was provided for other regions.