On June 28，2020，a case of suspected lumpy skin disease（LSD）was found in yellow cattle in a household in Xiuning County of Huangshan City. An outbreak investigation was carried out in the field by a specialist team assigned by relevant departments of Anhui Province，and samples of whole blood，skin nodules，nose/mouth swabs were collected for PCR test. It was confirmed that the outbreak was the LSD caused by LSD virus according to the epidemiological characteristics and the results of pathological examination and laboratory detection and in combination with the result of reexamination by National Center for Research on Exotic Animal Diseases. It was speculated that，upon investigation，the outbreak might be caused by the virus carried by insect vectors，persons or vehicles. Some suggestions were hereby put forward，such as，strengthening the control and extermination of arthropods as well as taking measures to eliminate mosquitoes and flies in farms，surrounding rivers and farmlands；improving bio-security management for farms，strictly controlling and disinfecting persons or vehicles that entered or left farms；publicizing the technologies for prevention and control of LSD and carrying out relevant trainings to make farmers fully understand the disease，so that they could better prevent and control the disease. Therefore，some references were provided for prevention and control of LSD.