In order to identify the prevention and control status of major animal diseases such as African swine fever（ASF），as well as the bio-safety construction in large-scale swine farms in Nanping City of Fujian Province，and to analyze key risk points of major disease control therein，an investigation was carried out in 267 farms across the city in January 2020，involving pig production，introduction，bio-safety and feeding management，self-inspection for ASF and other factors. It was found that，94.38% farms had been keeping pigs that were born therein，56.18% farms had never introduced any new pigs，and only 18.80% farms introduced pigs from other provinces outside of Fujian；the farms with the storage of 500 pigs or above accounted for 82.40%；93.26% farms were managed as per different areas，all persons and vehicles were disinfected when they entered or left the farms；97.00% farms were equipped with disposal facilities for dead pigs，87.27% farms were with platforms for transporting pigs outside，and 95.51% farms were with quarantine areas；42.32% farms purchased complete feed，70.41% farms used deep phreatic water，and 86.52% farms strictly controlled all movement of staff；77.90% farms carried out self-inspection for ASF. It was concluded that the farm scale and feeding management level were high，the bio-safety management was strict，and there existed obvious advantages in the prevention and control of major swine diseases such as ASF，therefore the risk of any outbreak could be controlled. However，some defects concerning bio-safety management were found in some farms where a bio-safety control system should be thoroughly implemented. Some references were provided for risk assessment and control of ASF in Nanping City.