基于网络药理学分析黄芪防控猪繁殖与呼吸综合征的物质基础及靶点信息
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Analysis on the Material Basis and Drug Targets of Astragalus Membranaceus in Prevention and Control of PRRS Based on Network Pharmacology
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    摘要:

    为揭示黄芪防控猪繁殖与呼吸综合征(PRRS)的物质基础及靶点信息,采用网络药理学方法,从中药系统药理学数据库与分析平台(TCMSP)筛选黄芪的潜在活性成分、作用靶点,同时从比较毒理基因组学数据库(CTD)收集PRRS相关宿主基因,最后构建“活性成分-关键靶点”网络、蛋白互作网络,并进行GO功能和KEGG通路富集分析。结果显示,从黄芪筛选出的17个潜在活性成分中,有14个潜在活性成分共计65个基因靶点与PRRS相关宿主基因交叉,其中槲皮素、山奈酚、刺芒柄花素、异鼠李素等潜在活性成分可能对治疗PRRS有重要作用,TNF、IL8、TP53、IL6、IL10、IL1B、JUN等45个蛋白靶点间存在相互作用。此外,黄芪治疗PRRS的作用机制可能涉及细胞外间隙和胞浆等组分,并可能与炎症反应、细胞凋亡、T细胞受体信号通路等生物过程相关。本研究为临床应用黄芪及其提取物治疗PRRS奠定了理论基础。

    Abstract:

    In order to reveal the information concerning the material basis and drug targets of astragalus membranaceus acting on porcine reproductive and respiratory syndrome(PRRS),the potential active components and drug targets related to astragalus membranaceus were screened through traditional chinese medicine systems pharmacology database and analysis platform(TCMSP)by the network pharmacology. Meanwhile,the host genes related to PRRS were gathered from comparative toxicogenomics database(CTD)to construct the“active components-key targets”network and protein-protein interaction(PPI)network,and to analyze the GO functions and KEGG pathway enrichment. The results showed that 14 out of 17 potential active components including 65 gene targets crossed with the host genes related to PRRS,especially,quercetin,kaempferol,formononetin,isorhamnetin and other potential active components played an important role in fighting against PRRS,and 45 targets could interact with each other,including TNF,IL8,TP53,IL6,IL10,IL1B and JUN. In addition,the mechanism of astragalus membranaceus in fighting against PRRS might involve extracellular space and cytoplasmic components,and might be related to biological processes such as inflammatory response,apoptosis,and T cell receptor signaling pathway. Therefore,a theoretical foundation was laid for clinical application of astragalus membranaceus and its extract in fighting against PRRS.

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陈志飞,司广斌,蔡蔚游,梁文清,韦柳明,周霞,贺东生.基于网络药理学分析黄芪防控猪繁殖与呼吸综合征的物质基础及靶点信息[J].《中国动物检疫》编辑部,2021,38(1):69-74.

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  • 在线发布日期: 2020-12-30
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