In order to identify the status of immune against foot-and-mouth disease（FMD）and peste des petits ruminants（PPR）in cattle and sheep in Yulin City of Guangxi，922 cattle serum and 2 244 sheep serum samples collected from 234 breeding farms，scale farms and free-range households in 7 counties（cities，district）of Yulin City were detected for antibodies against FMD-O，A and Asia I and PPR by enzyme-linked immunosorbent assay（ELISA）from the period of 2017 to 2019，and the levels of the above antibodies were compared by years and regions. The results showed that the farm/herd and individual qualified rates of antibodies against FMD-O in sheep and cattle generally remained above 70%，but were lower in certain regions（P＜0.05）；the qualified rate of antibodies against FMD Asia I was lower in 2017，but increased up to above 80% since 2018；that against FMD-A was generally lower than 70%，and that against PPR was increasing year by year and remained above 70%，without any regional difference（P＞0.05）. In conclusion，the overall immune effects against FMD-O and Asia I and PPR were relatively good，except the immune effect against FMD-A that was poor，indicating an uneven level in various regions to some extent. Vaccination and monitoring against FMD and PPR should be thus strengthened according to specific conditions in each region，so as to safeguard a high immune level in cattle and sheep there. Therefore，relevant technical support was provided for effective prevention and control of such diseases.