RNA病毒重组及发生机制
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东省农业科学院农业科技创新工程项目(CXGC2018E10);国家重点研发计划项目(2016YFD0500708);山东省重大科技创新项目(2019JZZY010720);山东省现代农业产业技术体系项目(SDAIT-08-07);山东省科技发展计划项目(2019GNC106151);山东省农业应用重大创新项目(SD2019XM003,SD2019XM006);泰山学者项目;山东省农业科学院科技创新计划项目(CXGC2016B14)


Recombination and the Mechanism of RNA Viruses
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    摘要:

    重组在RNA病毒中很常见,但有关重组的许多关键问题目前尚无法解释。本文主要针对RNA重组的发生机制及其影响因素,解释重组频率发生变化的原因,阐述RNA重组未来仍需解决的问题。RNA重组是RNA病毒特殊的遗传信息交换方式,其频率在不同的RNA病毒中显著不同。目前,研究者普遍认为重组发生的机制可分为复制型、非复制型重组以及重配,并且借助新方法和新技术,逐渐了解了影响该过程的病毒和细胞因子。有研究表明,RNA病毒中RNA的重组和重配率非常高,这与RNA依赖性RNA聚合酶(RdRp)的保真性相关。因此,深入了解病毒重组机制并发现其中的规律,可实现对新型病毒以及新疫情的预警预报,从而有预见性地控制疫病的发生和流行。

    Abstract:

    Recombination is widely observed in RNA viruses,but many key issues therein could not be explained till now. In the paper,the reasons for the change of recombination frequency were explained based on RNA recombination mechanism and the influencing factors,and relevant issues to be addressed in the future were stated. RNA recombination was a special way to exchange genetic information by RNA viruses,with different frequency in various RNA viruses. At present,it was generally believed by researchers that,the mechanism of recombination could include replication,non-replication and reassortment,and the viruses and cytokines that might affect the process were gradually recognized with the help of new methods and technologies. It was studied that the recombination and reassortment rate of RNA were extremely high in RNA viruses,which was related to the fidelity of dependent RNA polymerase(RdRp). Therefore,the new virus or outbreak could be early warned and reported through further recognition of the mechanism and rules of virus recombination,so as to control the occurrence and prevalence of animal diseases in a predictable way.

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李琛,时建立,彭喆,刘畅,徐绍建,韩红,吴晓燕,李俊. RNA病毒重组及发生机制[J].《中国动物检疫》编辑部,2021,38(2):82-92.

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  • 在线发布日期: 2021-02-01
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