Laboratory information management system（LIMS）was originally developed and applied for large and medium-sized laboratories，and was subsequently introduced into small laboratories，thus resulting in lots of problems to small labs due to the characteristics of numerous system modules，complex structure and difficulty in operation. In this paper，with a view to the analysis on working procedure and corresponding modules of LIMS，the configuration scheme of core module was put forward，which would achieve the goal of adapting LIMS to small laboratories，so as to improve the efficiency of laboratory testing.