In order to do a good job in the bio-safety disposal of diseased and died livestock and poultry，the bio-safety disposal system has been comprehensively established by Changsha authorities. The specific measures included strengthening the construction of information supervision platform，actively promoting local legislation，severely cracking down the illegal activities，exploring how to establish a long-term regulatory mechanism for bio-safety disposal. In this paper，the present situation of the bio-safety disposal work was summarized，the construction of the existing bio-safety disposal system in Changsha was analyzed，including the disposal center，collection and transfer center，temporary storage and bio-safety disposal points. Then the current problems were pointed out，such as difficulty in supervision，insufficient coverage of the farming insurance，the imperfect subsidy mechanism，as well as the incomplete legal system. At last，corresponding suggestions were pointed out，including increasing financial support，achieving full coverage of farming insurance，improving subsidy mechanism for bio-safety disposal，promoting the improvement of relevant laws and regulations and clarifying the division of responsibility，and so on.