Abnormal metabolism of body even a series of comprehensive metabolic diseases could be caused by obesity，however，studies on the mechanisms of potential molecular and biomolecular of obesity advanced relatively slow，one of major bottlenecks was the selection of animal models. In order to seek for the feasibility of application of model pigs to studies on human obesity，the advantages of such application were analyzed in terms of genome evolution and physiology，the limitations of rodent models were put forward，then the research progress of such model pigs was summarized. The similarity between genome of pigs and that of human was about 60%，their metabolic system models were also very similar，so were their digestive physiological functions，dietary habits，size of body organs and distribution of adipose tissues. Compared to other rodent models usually used，model pigs had been used for studies on prevention and treatment of human obesity diseases with certain achievements due to their superior advantages. It was concluded that model pigs would be a reliable choice for studies on human obesity diseases. More thoughts were provided by the paper for selection of model animals to be used for studies on human obesity.