The status of prevention and control of brucellosis in cattle and sheep in Anhui Province was analyzed based on the production data provided by Anhui Statistics Bureau，the Veterinary Health Comprehensive Platform and public health data. In 2020，the inventory of cattle and sheep across the province was as follows：81.25% in Huaibei region，about 16.59% in Jianghuai region and 2.16% in Jiangnan region. During 2016 to 2019，the individual positive rates were 0.05%，0.09%，0.14% and 0.59%，respectively，showing a slight upward trend；during 2015 to 2019，the cases of human brucellosis were 76，78，146，156 and136，respectively，which trended to increase. As it was investigated that there were some bottlenecks such as poor prevention and control of the disease，insufficient funding，lack of field inputs for animal disease prevention，gaps in regulation for cattle and sheep movement，unclear status of animal brucellosis，backward feeding modes，weak awareness for disease prevention，etc. Therefore，it was suggested to strengthen organization and guidance，support with budgets，construct a team for disease prevention at grassroots level，further purify the disease as well as guarantee the safety of breeding industry and public health.