天然免疫RIG-I样受体LGP2在抗病毒免疫中的作用
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S852.42

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国家自然科学基金项目(31872450,31672523);江苏高校优势学科建设工程资助项目(PAPD)


Studies on the Roles of Innate Immune RIG-I-like Receptor LGP2 in Antiviral Immunity
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    摘要:

    RIG-I样受体(RLRs)是细胞质中重要的模式识别受体(PRRs),LGP2是其重要的家族成员之一。LGP2在抗病毒天然免疫应答中具有特殊功能,能够双向调控RIG-I、MDA5介导的I型干扰素(IFNs)信号通路。在不同病毒感染宿主的过程中,LGP2也表现出明显的功能差异。在双链DNA病毒中,LGP2在RIG-I介导的信号传导过程中起正向调节作用;在单链DNA病毒中,LGP2能够促进CARDs区失活的RIG-I与非典型泛素链结合,从而诱导I型IFNs产生;在双链RNA病毒中,正常表达可增强RIG-I、MDA5对dsRNA的识别能力;在正义单链RNA病毒中,LGP2参与对正义单链RNA病毒的识别过程;在负义单链RNA病毒中,LGP2有时可作为IFNs的诱导剂。另外,LGP2在适应性免疫应答中也发挥着重要作用,能够通过不同途径调控T细胞存活与凋亡。目前在调控RIG-I、MDA5介导的信号通路与抗病毒免疫应答中,尚不清楚LGP2发挥的确切功能和其作用机制,未来可进一步加深LGP2在细胞免疫应答中的作用及机制研究。本文就近年来LGP2在RLRs介导的信号通路和抗病毒免疫应答中发挥的作用作综述,以期为LGP2的进一步研究和机体抵御病毒感染新机制提供参考。

    Abstract:

    RIG-I-like receptors(RLRs)are the key pattern recognition receptors(PRRs)in cytoplasm,and LGP2 is one of its important family members. LGP2 functions specially in antiviral innate immune response,and could regulate the type-I interferon(IFNs)signaling mediated by RIG-I and MDA5 bidirectional. Functional differences are also obviously present in LGP2 during the process of infection with different viruses in hosts.LGP2 positively regulates the progress of signaling mediated by RIG-I in double-stranded DNA(dsDNA)viruses,induces type-I IFNs through supporting the binding of inactivated RIG-I located in CARDs region with atypical ubiquitin chainin single-stranded DNA(ssDNA)viruses,increases the capacity of RIG-I and MDA5 to recognize dsRNA through normal expression in double-stranded RNA(dsRNA)viruses,participates in the process of recognition for positive-sense single-stranded RNA(+ssRNA)viruses,and is sometimes used as an inducer for IFNs in negative-sense single-stranded RNA(-ssRNA)viruses. In addition,LGP2 also plays an important role in adaptive immune response,regulating the survival and apoptosis of T cells through different ways. Currently,its specific functions and mechanisms for regulation of signaling mediated by RIG-I and MDA5 and for antiviral immune response are still unclear,which should be further studied in the future. In the paper,the studies on the roles of LGP2 in signaling mediated by RLRs and antiviral immune response in recent years were reviewed,with a view to providing a reference for further study on LGP2 and new mechanisms of resistance to viral infection.

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邵琦,曹琦,张佳佳,张友文,罗佳,刘学良,夏能文,朱建中.天然免疫RIG-I样受体LGP2在抗病毒免疫中的作用[J].《中国动物检疫》编辑部,2021,38(12):82-90.

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