In order to identify the advantages and feasibility of bacterial whole genome sequencing（WGS）in grassroots prevention and control of Salmonella，the bacterial whole genome of 9 isolated strains of Salmonella was sequenced，followed by serotype prediction，multilocus sequence typing（MLST）and analysis on drug resistance gene，to compare the results of WGS with those of traditional serotyping and drug resistance analysis. The results showed that the coincidence rate of serological typing based on WGS data was 100% with that of traditional serological typing，by both of which，the results of 9 strains of Salmonella serotyping were completely consistent；and the coincidence rate of drug resistance genes and drug resistance phenotype of β-lactams，chloramphenicols，quinolones and aminoglycosides was 100%，that was，drug resistance genes of four categories of antibiotics were contained in all drug-resistant strains；7 resistance genes of rifampicin，sulfanilamide and tetracycline were detected by WGS，indicating that the 9 strains of Salmonella might be resistant to these three categories of antibiotics. It was concluded that WGS was with the advantages such as rapidity，low cost and simple operation，its results were completely consistent with those by traditional laboratory diagnosis，and its costs and cycle for detection would be further reduced with the development of sequencing technology. Therefore，there would be certain value of application and feasibility to develop a method for rapid typing and drug resistance analysis of Salmonella based on bacterial whole genome sequencing.