In recent years，Angus beef cattle have been imported into Southern Xinjiang for breeding. In order to identify the epidemic status of major animal diseases and current biosafety problems in intensive farms in the region，four large and medium-sized intensive farms in Kashi region were investigated by means of field interview，questionnaire investigation and laboratory test. The results showed that the main clinical symptoms of the cattle included diarrhea，followed by pneumonia；the main viral pathogens causing calves diarrhea were bovine coronavirus（BCV）and bovine norovirus（BNoV），with positive detection rates of 19.93% and 15.20% respectively. Pneumonia was mainly caused by bovine infectious rhinotracheitis virus（IBRV）and bovine adenovirus type 3（BAV-3），with positive detection rates of 28.24% and 14.12% respectively. Potential dangers to different extent were found in the construction of disease prevention facilities and equipment，implementation of disinfection system，management and movement control of persons and materials，development of rules and regulations，feeding management，prevention and control of rodents and flies as well as biosafety disposal in the four farms. In conclusion，BCV，BNoV，IBRV，BAV-3 and other viruses should be strictly controlled in the farms，the incidence rate of diarrhea and pneumonia should be reduced by strengthening immunization，and any external pathogens should be avoided by strict biological safety control. A basis was thus provided for future prevention and control of animal diseases of Angus beef cattle imported to the region.