In order to scientifically evaluate the level of immune antibodies against highly pathogenic avian influenza（HPAI，H5 and H7 subtypes）in meat-type ducks and possible risk of outbreak under the condition of large-scale breeding in Liuzhou City，serum samples and throat/cloaca swabs were collected from duck farms across the city in 2021 for detection of antibodies and pathoges by hemagglutination inhibition test（HI）and fluorescent PCR assay，followed by statistical comparative analysis on the test results according to different serotypes，counties/districts and quarters. The results showed that the total qualified rates of the antibodies against H5 and H7 subtypes were 76.48%（3 472/4 540）and 68.00%（3 087/4 540）with the average titers of 5.52log2 and 4.20log2，respectively；it was compared that，through Chi square test，the former was obviously higher than the latter（P＜0.01）. No H5 or H7 subtype virus was detected in any pathogenic samples. The qualified rate of antibodies against avian influenza（AI）was different depending on different regions，especially that at county level was significantly higher than that at urban level（P＜0.01）. The total qualified rate in different quarters in sequence was the fourth＞the second＞the first＞the third. In conclusion，the immune effect of H5 and H7 subtype AI was generally good in Liuzhou City，with relatively low risk of HPAI outbreak；but it was still necessary to strengthen monitoring and risk assessment throughout the year，and focus on supplementary and intensive immunization in some urban areas，so as to build an effective immune barrier to prevent any occurrence of AI outbreak，and to ensure healthy development of poultry industry.